Polynucleotides — Regenerative Skin Support Treatment

Natural, Cellular-Level Rejuvenation for Skin, Neck, Décolletage, and Scalp

Polynucleotides are an advanced regenerative treatment that works at a deep cellular level to improve skin quality, texture, hydration, elasticity, and overall tissue health. Unlike traditional fillers, which primarily restore volume, polynucleotides support your skin’s own repair mechanisms — stimulating collagen and elastin production, enhancing hydration, and improving skin resilience and radiance.

This treatment is ideal for patients in London and North London seeking natural, non-surgical rejuvenation for the face, neck, décolletage, and scalp, helping to restore healthy, youthful-looking skin from within.

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What Are Polynucleotides?

Polynucleotides are long chains of purified DNA fragments derived from sources similar to human DNA. When injected into the skin, they act as biological biostimulators, signalling cells to repair and regenerate tissue naturally.

In aesthetic medicine, polynucleotides are used to:

  • Enhance skin quality, firmness, and elasticity

  • Deeply hydrate the skin

  • Stimulate collagen and elastin production

  • Reduce fine lines, wrinkles, and crepey skin

  • Support healing and improve texture, tone, and radiance

Unlike traditional fillers, polynucleotides work with your body’s natural processes to improve biological repair mechanisms rather than just masking the visible signs of ageing.

How Polynucleotides Work

When injected beneath the skin surface, polynucleotides provide multiple benefits:

Cellular Stimulation: They activate fibroblasts — the cells responsible for collagen and elastin production — improving skin structure, elasticity, and resilience over time.

Hydration Boost: Polynucleotides attract and retain water molecules, enhancing deep hydration and plumping tissue without adding artificial volume.

Anti-Inflammatory Support: They help reduce inflammation, calm irritation, and support tissue healing after aesthetic procedures.

Skin Regeneration: By promoting cellular repair and encouraging collagen formation, they improve overall texture, tone, and skin health.

This makes polynucleotides a versatile regenerative option for natural, non-surgical skin rejuvenation in London and North London, suitable for those looking to restore youthful skin quality and vitality.

Who Can Benefit from Polynucleotides?

Polynucleotide treatments are suitable for adults in London and North London seeking to:

  • Improve skin texture, firmness, and elasticity

  • Reduce fine lines, wrinkles, and crepey skin

  • Revitalise the under-eye area and delicate zones

  • Enhance neck, décolletage, or hand rejuvenation

  • Support post-procedure healing and recovery

  • Strengthen hair follicles and scalp health when used for scalp injections

They are ideal for patients looking for natural, cellular-level rejuvenation without volumising fillers, surgery, or significant downtime.

Perfect For

  • Under-eye rejuvenation treatment using polynucleotides to improve dark circles, fine lines, and skin hydration in London

    EYES

    Polynucleotides Eyes is an advanced regenerative treatment that helps reduce under-eye bags and smooth periocular wrinkles. It works by strengthening and restructuring the delicate tissue around the eyes, improving the appearance of fine lines and superficial wrinkles without the need for dermal fillers. Ideal for patients in London and North London seeking natural under-eye rejuvenation.

  • Full-face rejuvenation and collagen stimulation with polynucleotides regenerative treatment for improved skin firmness, texture, and hydration in London

    FACE

    Polynucleotides are an advanced regenerative treatment that helps restore skin tone and elasticity on the face. It reduces fine lines and wrinkles, improves hydration, enhances facial contour, and supports subtle lifting by targeting skin laxity and firmness. Ideal for patients in London and North London seeking natural, non-surgical facial rejuvenation.

  • Neck rejuvenation and improved skin elasticity with polynucleotides regenerative treatment in London

    NECK

    Polynucleotides can be effectively used on the neck to improve skin laxity, enhance skin tone, and boost elasticity, providing natural, non-surgical rejuvenation for patients in London and North London.

  • Polynucleotides treatment supporting thinner hair and scalp health as part of regenerative aesthetic care in London and North London

    HAIR

    Polynucleotides can help improve hair thinning and reduce hair loss. Its deep and continuous biorestructuring effect makes it suitable for a variety of hair concerns, including androgenic alopecia, postpartum hair loss, stress-related hair loss, and telogen effluvium, or as a preventative treatment. Ideal for patients in London and North London seeking natural, non-surgical scalp rejuvenation.

Treatment Journey

  • patient consultation for Polynucleotide treatment with Dr Marco Nicoloso to tailor skin rejuvenation goals

    CONSULTATION

    All treatments are provided following a mandatory face-to-face medical consultation to assess suitability. This includes a full medical history review and detailed facial assessment. A personalised treatment plan is then developed to address individual concerns and achieve safe, appropriate, and effective outcomes.

  • Polynucleotide regenerative skin treatment performed by Dr Marco Nicoloso in north london

    TREATMENT

    Performing injectable treatments requires an in-depth understanding of facial anatomy, a detailed skin and facial assessment, and a skilled, artistic approach to achieve natural-looking results. This treatment involves the precise injection of polynucleotides into the skin to stimulate regeneration, improve hydration, and enhance overall skin quality.

    For patients with sensitive skin, a topical numbing cream can be applied beforehand to ensure maximum comfort. The procedure is performed in a single appointment, typically lasting up to 30 minutes, and is suitable for patients in London and North London seeking safe, non-surgical skin rejuvenation.

  • post‑Polynucleotide treatment review and medical grade skincare advice to support long‑lasting rejuvenation

    REVIEW & SKINCARE

    A follow-up review is generally recommended 2–4 weeks after treatment to assess whether additional product may be needed. Patients may experience mild bruising, redness, temporary tenderness, or swelling, which typically resolves quickly. Depending on the treatment area and product used, results can last up to 6–8 months.

    As part of the consultation, a medical-grade skincare regimen is advised to protect and enhance skin quality, helping to prolong and optimise the results of the treatment. This approach is suitable for patients in London and North London seeking natural, long-lasting skin rejuvenation.

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  • Polynucleotides are a viscoelastic, sterile, non-pyrogenic, absorbable intradermal injectable solution made from polymerized polynucleotides. This innovative treatment provides an effective way to restore skin firmness and elasticity, while supporting overall skin health and protecting against free radicals and cellular damage.

    Ideal for patients in London and North London, polynucleotides offer a natural, non-surgical approach to rejuvenating the skin, improving texture, and enhancing radiance.

  • Polynucleotides act as a biostimulator, supporting the skin’s natural repair and regeneration processes. Results are not permanent but can last up to 8 months, with an optimal course of three treatments spaced two weeks apart. This treatment is suitable for patients in London and North London seeking natural, non-surgical skin rejuvenation.

  • The polynucleotides used in treatment are highly purified, free from proteins or other components that could trigger an immune response. Common temporary side effects may include tenderness, mild bruising, and swelling, which typically resolve quickly. Allergic reactions or serious complications are extremely rare and are fully discussed during the consultation.

    For safety and optimal results, polynucleotide treatments should only be performed by medically trained practitioners. This approach is suitable for patients in London and North London seeking safe, professional, non-surgical skin rejuvenation.

  • Ameela is injected with a very small needle or cannula and the treatment is not painful. You may experience mild stinging during the injection which will subside in a couple of minutes.

  • Polynucleotides are a popular regenerative treatment across all age groups due to the visible improvements they deliver, particularly for those addressing signs of ageing. The treatment is not suitable during pregnancy or while nursing.

  • Initial improvements are often visible immediately after treatment, with final results typically appearing 4–6 weeks after the second session.

FREQUENTLY ASKED QUESTIONS

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Dr Marco is a wizard. The whole experience was fabulous from start to finish. The team have thought of everything and the entire process is professional and seamless. I wouldn’t hesitate to recommend.

CLIENT TESTIMONIAL